PREPARATION AND CHARACTERIZATION OF A NEAR-INFRARED LIGHT RESPONSIVE MICROCAPSULE SYSTEM FOR CANCER THERAPY

作     者：YINGFENG DI SISI CUI YUEQING GU 

作者机构：Department.of Biomedical Engineering School of Life Science and Technology China Pharmaceutical University 24 Tongjia LaneGulou District Nanjing 210009P.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2014年第7卷第1期

页      面：26-32页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：grateful to Natural Science Foun-dation Committee of China(NSFC 81220108012,81171395,81071194,81000666,30970776,30672015,30800257and 31050110123) the Ministry,of Scienceand Technology(2009ZX09310-004) the Pri-ority Academic Program Development of Jiangsu Higher Education Institutions for their financial support 

主　　题：Microcapsules self-assenbly NIR-irradiation cancer research. 

摘      要：A novel near-infrared light responsive microcapsule sy stem,gold nanorod-covered DoX-loadedhollow CaCO;microcapsule(AuNR-HM-DOX)is developed for cancer *** hollowCaCOs microcapsules were prepared based on the selfassembly between chitosan and sodiumalgimate on CaCOs Particles via layer-by-layer technique,and then coveredl with gold nanorods toobtain the microcapsule *** near-infrared(NIR)irradiation,microcapsule with goldnanorods can convert the absorbed NIR light into ***,doxorubicin(DOX),a *** drug,is loaded into the microcapsule system via electrostatic adsorption for combinedphotothermal therapy and chemotherapy,Properties of AuNR-HM-DOX including grain dia-meter,optical spectra were characterized Confocal fluorescence imaging was performed to observet he morphology of the capsules and existence of D OX in the core,confrming t he successful loading of *** release of DOX from the capsules under continuous NIR rradiation was investigatedto evaluate the temperat ure responsiveness of *** indicate that *** microcapsules possess uniform particle size and high light *** combination of chemical and physical therapy of AuNR-HMDOX features great potential as an adjuvanttherapeutic alternative material for combined cancer therapy.