Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China

作     者：LI ChunYan WANG WeiZhuo GUO Xlong ZHANG Feng MA WeiJuan ZHANG YinGang LI YouFen BAI YiDong LAMMI Mikko J 

作者机构：Faculty of Public Health Medical College of Xi'an Jiaotong University Key Laboratory of Environment and Gene Related Diseases of Min- istry of Education Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health Xi'an 710061 China 1nstitute of Health Education of Xi'an Xi'an 710004 China Department of Orthopedics Surgery Second Hospital Xi'an Jiaotong University Xi'an 710004 China Department of Orthopedics Surgery First Hospital Xi'an Jiaotong University Xi'an 710061 China School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 China Department of Cellular and Structural Biology University of Texas Health Sciences Center at San Antonio San Antonio Texas 78229 USA Department of Anatomy Institute of Biomedicine University of Kuopio Kuopio F1N-70211 Finland 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2012年第55卷第12期

页      面：1057-1063页

核心收录：

学科分类：0710[理学-生物学] 090603[农学-临床兽医学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 09[农学] 0906[农学-兽医学] 071002[理学-动物学] 

基　　金：supported in part by the National Natural Science Foundation of China (Grant No. 30972556) the Key Scientific and Technological Innovation Special Projects of Shaanxi "13115" of China (Grant No. 2009ZDKG-79) the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20090201110049) 

主　　题：Kashin-Beck disease microarray mitochondrial dysfunction IPA analysis 

摘      要：In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.