Meta-analysis of risk factors for Parkinson’s disease dementia

作     者：Yaqian Xu Jing Yang Huifang Shang 

作者机构：Department of NeurologyWest China HospitalSichuan University610041 ChengduSichuanChina 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2016年第5卷第1期

页      面：87-94页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Parkinson’s disease Dementia Risk factors Predictors 

摘      要：Background:Parkinson’s disease(PD)is a common heterogeneous neurodegenerative disorder in elder ***’s disease dementia(PDD)is one of the most common non-motor manifestations in PD *** comprehensive review has been conducted to assess risk factors for ***:A systemic search for studies on PDD risk factors was *** and case–control studies that clearly defined PDD and presented relevant data were *** data were analyzed to generate a pooled effect size and 95%confidence interval(CI).Publication bias was assessed using the Egger’s test and the Begg’s ***:A systematic search was conducted and yielded 5195 *** screening,25 studies were included in the current *** of PDD was positively associated with age(odds ratio[OR]1.07,95% CI 1.03-1.13),male(OR 1.33,95% CI 1.08-1.64),higher Unified Parkinson’s Disease Rating Scale(UPDRS)part III scores(relative risk[RR]1.04,95% CI 1.01-1.07),hallucination(OR 2.47,95% CI 1.36-4.47),REM sleep behavior disorder(RBD)(OR 8.38,95% CI 3.87-18.08),smoking(ever ***)(RR 1.93,95% CI 1.15-3.26)and hypertension(OR 1.57,95% CI 1.11-2.22).An inverse association was found between education(RR 0.94,95% CI 0.91-0.98)and *** reported factors,including age of onset,disease duration of PD,Hoehn and Yahr stage and diabetes mellitus were not significantly associated with ***:Advanced age,male,higher UPDRS III scores,hallucination,RBD,smoking and hypertension increase the risk of PDD,whereas higher education is a protective factor for PDD.