Synthesis,Crystal Structure and DNA Interaction of a Chiral Platinum(Ⅱ)Complex with 2-(2,3-Dimethoxyphenyl)-1H-imidazo[4,5-f][1,10]phenanthroline

作     者：罗旭健 王书龙 杨燕 罗志辉 刘荣军 梁伟江 

作者机构：Guangxi Key Laboratory of Farm Products Processing (Cultivation Base)Colleges and Universities Key Laboratory for Efficient Use of Agricultural Resources in the Southeast of GuangxiCollege of Chemistry and Food ScienceYulin Normal University 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2017年第36卷第9期

页      面：1486-1492页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 10[医学] 

基　　金：supported by NNSFC(Nos.51463023 and 21461028) Scientific Research Project of Guangxi Colleges and Universities(No.2013YB201) 

主　　题：phenanthroline platinum complex DNA interaction 

摘      要：A new platinum（Ⅱ） complex of [Pt（chda）（2,3-dmopip）]Cl·H2O（1, chda = cyclohexan-ediamine, 2,3-dmopipH = 2-（2,3-dimethoxyphenyl）-1H-imidazo[4,5-f][1,10]phenanthroline） has been synthesized by hydrothermal methods and characterized by elemental analysis, IR, single-crystal X-ray diffraction, UV-vis and fluorescent spectrum. In complex 1, the platinum adopts a four-coordinated square planar geometry. The DNA-binding interaction has been investigated. The complex can bind to DNA by an intercalative mode, presenting high DNA-binding affinity.