Controlled Cell Patterning on Bioactive Surfaces with Special Wettability

作     者：Xiaofeng Zhou Jiaqian Li Hongyan Sun Yi Hu Lufeng Che Zuankai Wang 

作者机构：Science and Technology on Microsystem Laboratory Shanghai Institute of Microsystem and lnformation Technology Chinese Academy of Sciences Shanghai 200050 China Department of Mechanical and Biomedical Engineering City University of Hong Kong Hong Kong 999077 China Department of Biology and Chemistry City University of Hong Kong Hong Kong 999077 China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Multi-disciplinary Research Division Institute of High Energy Physics Chinese Academy of Sciences (CAS) Beijing 100049 China College of Biomedical Engineering & Instrument Science Zhejiang University Hangzhou 310027 China 

出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)

年 卷 期：2017年第14卷第3期

页      面：440-447页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0832[工学-食品科学与工程（可授工学、农学学位）] 081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程] 083203[工学-农产品加工及贮藏工程] 0702[理学-物理学] 

基　　金：This work was supported by Grant of Science and Technology on Microsystem Laboratory （9140C180105150C1809）  the RGC Grant （11213414）  the National Basic Research Program of China （2012CB933302）  and National Natural Science Foundation of China （21390411）. 

主　　题：cell patterning wettability superhydrophilic surface chemistry circulating tumor cells 

摘      要：The ability to control cell patterning on artificial substrates with various physicochemical properties is of essence for important implications in cytology and biomedical fields. Despite extensive progress, the ability to control the cell-surface interaction is complicated by the complexity in the physiochemical features of bioactive surfaces. In particular, the manifesta- tion of special wettability rendered by the combination of surface roughness and surface chemistry further enriches the cell-surface interaction. Herein we investigated the cell adhesion behaviors of Circulating Tumor Cells （CTCs） on topog- raphically patterned but chemically homogeneous surfaces. Harnessing the distinctive cell adhesion on surfaces with different topography, we further explored the feasibility of controlled cell patterning using periodic lattices of alternative topographies. We envision that our method provides a designer＇s toolbox to manage the extracellular environment.