Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice

作     者：Yingyi Pan Zhifeng Chu Wenjuan Wang Baican Yang 

作者机构：Department of Traditional Chinese Medicine School of Pharmacy Shanghai University of Traditional Chinese Medicine Department of Traditional Chinese Medicine Shanghai Songjiang Fangta Hospital 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2013年第33卷第6期

页      面：794-797页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by a Grant from Shanghai Municipal Science and Technology Commission(No.08DZ1972105) 

主　　题：Uric acid Hyperuricemia Pretreatment Jieduxiezhuo decoction 

摘      要：OBJECTIVE: To investigate whether Jieduxiezhuo decoction(JDXZD) can prevent serum uric acid elevations in mice. METHODS: Hyperuricemia in mice was induced by intraperitoneally administering uric acid(250 mg/ kg). Concentrations of uric acid in serum were determined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered. RESULTS: After intraperitoneal injection of uric acid, serum uric acid concentrations in mice significantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups. CONCLUSION: Pretreatment with JDXZD slowed increases in serum uric acid levels in mice intraperito-neally administered uric acid.