Uncinatic acids A-C,three new carboxylated flavonoids from Selaginella uncinata

作     者：Rui Liu Hui Zou Ping-Sheng Xu Zhen-Xing Zou Jing Li Fei Cheng Rui-Huan Liu Gan Zhou Kang-Ping Xu Gui-Shan Tan 

作者机构：Xiangya Hospital of Central South UniversityChangsha 410008China Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410013China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第7期

页      面：1465-1468页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 0703[理学-化学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.31370370) Key Project of Science and Technology of Hunan Province,China(Nos.2014SK2002 and 2013SK5077) Key Project of Application Technology Research and Development of Haikou(No.2015-039) Social Development and Technology Specific Program of Hainan Province(No.SF201419) 

主　　题：Selaginella uncinata Selaginella Uncinatic acids A C Carboxylated flavonoids Furanoflavonoids Anticancer Cytotoxicity 

摘      要：Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.