Identification of long non-coding RNA p34822 as a potential plasma biomarker for the diagnosis of hepatocellular carcinoma

作     者：Cheng Wang Tianyu Ren Keyu Wang Shaogeng Zhang Shubin Liu Hu Chen Penghui Yang 

作者机构：The 307 Hospital Of PLA Beijing 100071 China The 302 Hospital Of PLA Beijing 100039 China Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and Biosecurity Beijing 100071 China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2017年第60卷第9期

页      面：1047-1050页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Natural Science Foundation of Beijing Municipality(CN7162185) 

主　　题：原发性肝细胞癌 生物标志物 早期诊断 非编码RNA 鉴定 血浆 肿瘤标志物 早期治疗 

摘      要：Dear Editor,Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide(Li and Satomura,2015).Early diagnosis and treatment are vital for reducing ***,biomarkers such as serum alpha fetoprotein(AFP),AFP-L2,and carcinoembryonic antigen are widely used tumor markers for managing HCC in patients(Shi et al.,2016).However,because of their low diagnostic sensitivity and specificity,novel biomarkers with high sensitivity and specificity for early HCC diagnosis are needed.