Effect of Jianpiyiqi granule on ocular myasthenia gravis in children prepared with a formula from Traditional Chinese Medicine

作     者：Qi Guoyan Liu Peng Gu Shanshan Yang Hongxia Dong Huimin Xue Yinping 

作者机构：Center of Treatment of Myasthenia Gravis First Hospital of Shijiazhuang Shijiazhuang 050011 China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2017年第37卷第4期

页      面：546-553页

核心收录：

学科分类：1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Shijiazhuang Science and Technology Bureau Foundation(No.131460613) Science and Technology Agency Foundation of Hebei Province(grant no.14277758D) Natural Science Foundation of Hebei Province(No.H2015106020) Key Project of Hebei Provincial Administration of Traditional Chinese Medicine(No.2014221) 

主　　题：Myasthenia gravis Receptors, cholinergic Autoantibodies Cytokines Neuromuscular junction Jianpiyiqi granule 

摘      要：OBJECTIVE: To investigate the effect of Jianpiyiqi granule, prepared according to a Traditional Chinese Medicine(TCM) formula, on the ocular type of myasthenia gravis(MG) caused by a defect in synaptic transmission at the neuromuscular ***: A total of 155 children with ocular MG were recruited from January 2008 to January *** individuals received ineffective glucocorticoid treatment prior to admission, and were given Jianpiyiqi granules(two doses per day) for 12 *** levels of acetylcholine receptor autoantibodies(ACh R-Ab), cytokines, immune parameters and clinical score were ***: After intervention with Jianpiyiqi granule for 12 months, the levels of cytokines [including interleukin(IL)-6, IL-12, IL-17], immune parameters[including immunoglobulin G(Ig G), Ig M, free triiodothyronine, free thyroxine] and ACh R-Ab were sig-nificantly decreased(P = 0.042, P = 0.049, P = 0.011,P = 0.02, P = 0.04, P = 0.03, P = 0.01; F = 21.60, P =0.000). In contrast, IL-4 levels were significantly increased(P = 0.049). The absolute clinical score after treatment declined significantly compared with before treatment(F = 33.24, P = 0.000). The effective cure rate and the total effective rate gradually increased to a maximum of 149(96.2%) and 151(97.4%) in MG patients after 12 months of treatment, ***: The Jianpiyiqi granule treatment lowered ACh R-Ab levels and improved cytokine and other immune parameter levels, which suggests that the granule could be an ancillary treatment for ocular MG in children caused by a defect in synaptic transmission at the neuromuscular junction.