Nucleophilic Difluoro(phenylsulfonimidoyl)methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF_(2)H: Facile Entry into gem-Difluoroalkenes

作     者：Xiao Shen Qinghe Liu Chuanfa Ni Jinbo Hu 

作者机构：Key Laboratory of Organofluorine ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2014年第32卷第8期

页      面：703-708页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Support of our work by the National Basic Research Program of China(Nos.2012CB215500 and 2012CB821600) the NNSFC(No.21372246) Shanghai QMX program(No.13QH1402400) the Chinese Academy of Sciences is gratefully acknowledged 

主　　题：nucleophilic fluoroalkylation β-elimination difluoroalkene sulfoximine 

摘      要：An efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF_(2)H has been *** is particularly remarkable that,when 1.5 *** alkyl bromides are used,the substitution products are obtained in moderate to excellent *** prepared difluoro(phenylsulfonimidoyl)methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediatedβ-elimination reaction.