Neurofilament proteins in axonal regeneration and neurodegenerative diseases

作     者：Haitao Wang Minfei Wu Chuanjun Zhan Enyuan Ma Maoguang Yang Xiaoyu Yang Yingpu Li 

作者机构：Department of Spine Surgery China-Japan Union Hospital Jilin University Changchun 130033 Jilin Province China Department of Orthopedic Surgery Beihua University Affiliated Hospital Jilin 132000 Jilin Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第8期

页      面：620-626页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 071006[理学-神经生物学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the National Natural Science Foundation of China  No. 30872609 

主　　题：axonal regeneration nerve injury neurodegenerative diseases neurofilament protein post-transcriptional regulation reviews 

摘      要：Neurofilament protein is a component of the mature neuronal cytoskeleton, and it interacts with the zygosome, which is mediated by neurofilament-related proteins. Neurofilament protein regulates enzyme function and the structure of linker proteins. In addition, neurofilament gene expression plays an important role in nervous system development. Previous studies have shown that neurofilament gene transcriptional regulation is crucial for neurofilament protein expression, especially in axonal regeneration and degenerative diseases. Post-transcriptional regulation increased neurofilament protein gene transcription during axonal regeneration, ultimately resulting in a pattern of neurofilament protein expression. An expression imbalance of post-transcriptional regulatory proteins and other disorders could lead to amyotrophic lateral sclerosis or other neurodegenerative diseases. These findings indicated that after transcription, neurofilament protein regulated expression of related proteins and promoted regeneration of damaged axons, suggesting that regulation disorders could lead to neurodegenerative diseases.