Anchanling reduces pathology in a lactacystin-induced Parkinson's disease model

作     者：Yinghong Li Zhengzhi Wu Xiaowei Gao Qingwei Zhu Yu Jin Anmin Wu Andrew C. J.Huang 

作者机构：Shenzhen Second People＇s Hospital First Affiliated Hospital of Shenzhen University Shenzhen 518035 Guangdong Province China Shenzhen Institute of Gerontology Second Clinical Medical College Jinan University Shenzhen 518020 Guangdong Province China Larry Hillblom Islet Research Center David Geffen School of Medicine UCLA Los Angeles CA 90024 USA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第3期

页      面：165-170页

核心收录：

学科分类：090603[农学-临床兽医学] 0710[理学-生物学] 07[理学] 09[农学] 0906[农学-兽医学] 071006[理学-神经生物学] 

基　　金：supported by the National Natural Science Foundation of China (Influence of Anchanling on endoplasmic reticulum stress and ubiquitin-proteasome system in PD model)  No. 30772757 

主　　题：Parkinson's disease Anchanling ubiquitin-proteasome system α-synuclein tyrosine hydroxylase cell apoptosis 

摘      要：A rat model of Parkinson＇s disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson’s disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson＇s disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system.