Chromatographic Resolution of a-Amino Acids by （R）-（3,3＇-Halogen Substituted-l,l＇-binaphthyl）-20-crown-6 Stationary Phase in HPLC
Chromatographic Resolution of a-Amino Acids by （R）-（3,3＇-Halogen Substituted-l,l＇-binaphthyl）-20-crown-6 Stationary Phase in HPLC作者机构：Department of Chemistry Yunnan Normal University Kunming Yunnan 650500 China Department of Traditional Chinese Medicine Yunnan University of Traditional Chinese Medicine Kunming Yunnan 650500 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2017年第35卷第7期
页 面：1037-1042页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 070303[理学-有机化学] 0703[理学-化学]
基 金：This work was supported by the National Natural Science Foundation of China (Nos. 21675141 21165022)
主 题：α-amino acid chiral crown ethers stationary phase high-performance liquid chromatography
摘 要：Three new chiral stationary phases （CSPs） for high-performance liquid chromatography were prepared from R-（3,3＇-halogen substituted-1,1＇-binaphthyl）-20-crown-6 （halogen=C1, Br and I ）. The experimental results showed that R-（3,3＇-dibromo-l,l＇-binaphthyl）-20-crown-6 （CSP-1） possesses more prominent enantioselectivity than the two other halogen-substituted crown ether derivatives. All twenty-one a-amino acids have different degrees of sep- aration on R-（3,3＇-dibromo-l,l＇-binaphthyl）-20-crown-6-based CSP-1 at room temperature. The enantioselectivity of CSP-1 is also better than those of some commercial R-（1, 1＇-binaphthyl）-20-crown-6 derivatives. Both the separa- tion factors （a） and the resolution （Rs） are better than those of commercial crown ether-based CSPs [CROWNPAK CR（＋） from Daicel] under the same conditions for asparagine, threonine, proline, arginine, serine, histidine and va- line, which cannot be separated by commercial CR（＋）. This study proves the commercial usefulness of the R-（3,3＇-dibromo- 1, 1＇-binaphthyl）-20-crown-6 chiral stationary phase.
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