CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles

作     者：Wei DENG Ye Feng WANG Chen ZHANG Lei LIU Qing Xiang GUO 

作者机构：Department of Chemistry University of Science and Technology of China Hefei 230026 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第3期

页      面：313-316页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：国家自然科学基金(20332020 20472079) 

主　　题：Cross coupling reaction CuI N-arylation nitrogen heterocycle proline. 

摘      要：Ma＇s CuI/proline procedure for the catalytic cross coupling between nitrogen heterocycles and aryl halides was markedly improved. The key finding was that K3PO4 was a much better base than K2CO3 for the reaction. With this new reaction condition the cross coupling with aryl iodides could be accomplished in 1,4-dioxane instead of DMSO. This reactin also could be carried out in DMF. Furthermore, the coupling yields under the new conditions are usually higher than in Ma＇s original methods.