Novel Chiral Aminophosphine Ligand: Synthesis and Application in Asymmetric Catalytic Hydrogenation Reaction

作     者：陈亿新 李月明 林剑虹 陈新滋 

作者机构：Department of Chemistry Guangzhou University Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery & Synthesis Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2003年第21卷第1期

页      面：66-70页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：ProjectsupportedbytheNaturalScienceFoundationofGuangdongProvince (No .0 11839)andtheHongKongPolytechnicUniversityASDFundandUniversityGrantsCommitteeAreaofExcellenceSchemeinHongKong (AoEP/10 0 1) 

主　　题：aminophosphine chiral ligand 6,6′-dimethoxy-2,2′- bis(diphenylphosphinoamino)biphenyl asymmetric hydrogenation 

摘      要：A new chiral aminophosphine ligand 6,6′-dimethoxy-2,2′-bis(di~phenyl~phosphinoamino)biphenyl (DMBDPPABP) was prepared and its rhodium complex was found to be an effective catalyst for the asymmetric hydrogenation of amidoacrylic acid and its derivatives. The effects of solvent and reaction temperature on enantioselectivity were also studied.