Bis(7)-Tacrine Ameliorates Cognitive Impairment Caused by Cerebral Hypoperfusion in Rats

作     者：Peng Fang-fang Zhang Bai-fang Zhang Jiang-zhou Wu Dong-cheng Peng Fang-fang,Zhang Bai-fang,Zhang Jiang-zhou,Wu Dong-cheng *k Department of Biochemistry, School of Medicine , Wuhan University, Wuhan 430071, Hubei,China

作者机构：Department of BiochemistrySchool of MedicineWuhan UniversityWuhan 430071HubeiChina 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报(自然科学英文版))

年 卷 期：2002年第7卷第2期

页      面：248-252页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：SupportedbytheNationalNaturalScienceFoundationofChina(No:30 170 335 ) 

主　　题：bis(7)-tacrine acetylcholinesterase inhibitor permanent bilateral occlusion of common carotid arteries vascular dementia 

摘      要：The effects ofbis(7)-tacrine, a novel acetylcholinesterase inhibitor, on cognitive impairment and neuronal degeneration induced by permanent ligation of bilateral common carotid arteries (2VO) were investigated using the Morris water maze in rats. Once daily oral administration ofbis(7)-tacrine (0.025, 0.05 and 0.1 mg?kg?1) was started 14 days after 2VO operation. Over a three-week treatmentbis(7)-tacrine effectively reversed 2VO-induced spatial memory deficits in a dose-dependent fashion. Furthermore, histological observation showedbis(7)-tacrine decreased the neuropathological changes in the 2VO rats brain. These results suggest thatbis(7)-tacrine has therapeutic potential for the treatment of dementia caused by chronic cerebral hypoperfusion.