绝经后妇女经雌激素治疗后血浆一氧化氮代谢物浓度上升,但血流介导的血管扩张反应仅在较年轻妇女中上升

作     者：López-Jaramillo P Daz L.A Pardo A 王雅楠 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第5期

页      面：28-29页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：雌激素治疗 血浆一氧化氮 代谢物浓度 血流介导 血管扩张 葡萄糖水平 安慰剂对照 对比性分析 洗期 极限分析 

摘      要：To evaluate the effect of estrogen therapy (ET) on endothelial nitric oxide (N O) production and in flow-mediated vasodilation (FMV). Randomized, crossover, d ouble-blind, placebo-con-trolled study. Healthy postmenopausal women in an ac ademic research environment. Forty postmenopausal women between 45 and 72 years of age. Women received ET or placebo during two periods of 12 weeks that were se parated by 2 weeks of washout. Flow-mediated vasodilation, nitrite and nitrate, lipid profile, creatinine, and glucose were measured at weeks 12 and 24. Studen t’s t or Wilcoxon tests were used for comparative analyses, and κ.test and lim it analysis determined variability. After placebo treatment, nitrate and nitrite mean concentration was 8.28 ±1.17 mmol/L; it increased to 62.6 ±12.82 mmol/L after ET. Percentage FMV was 18.8 ±2.58 after the placebo period and did not ch ange after ET (20.1 ±1.92) in the whole sample, but in the subgroup (n = 15) of younger women (4550 years of age), percentage FMV increased from 13.6 ±3.6 aft er the placebo period to 22.2 ±3.5 after ET. An increase in plasma concentratio ns of nitrite and nitrate after ET was observed in all the women studied, but th e improvement in FMV was observed only in the younger ones. These age-related d ifferences in FMV in response to ET must be further investigated.