Potentiometric determination of mefenamic acid in pharmaceutical formulation by membrane sensor based on ion-pair with basic dye

作     者：Zholt Kormosh Oksana Matviychuk 

作者机构：Eastern European National University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2013年第24卷第4期

页      面：315-317页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 080202[工学-机械电子工程] 08[工学] 0703[理学-化学] 0802[工学-机械工程] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Mefenamic acidPVC membrane sensorsPotentiometryPharmaceutical analysis 

摘      要：The characteristics, performance and application of membrane sensors based on ion-pair Brilliant Green mefenamate are described. The sensor＇s response to the mefenamate ion has the sensitivity of （86.0 ± 2.0） mV/pC over the range of 9 × 10 s-I × 10 2 mol/L and the detection limit of 4.5 ×10 s mol/L at pH 8.5-12. The sensor is easily assembled at a relatively low cost and has fast response time （5-10 s）. The proposed sensor displayed good selectivity for mefenamate ion in the presence of different substances. It was used to determine mefenamic acid in pharmaceuticals.