Older age at first birth is a risk factor for pancreatic cancer： a meta-analysis

作     者：Ai-Jing Luo Rui-Hua Feng Xiao-Wan Wang Fu-Zhi Wang 

作者机构：The Third Xiangya Hospital of Central South University Changsha 410013 China Key Laboratory of Medical Information Research (Central South University) College of Hunan Province Changsha 410013 China School of Public Health Central South University Changsha 410078 China Center for Health Policy and Management China Academy of Medicine Sciences Beijing 100020 China Department of Medicine Management Bengbu Medical College Bengbu 233030 China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2016年第15卷第2期

页      面：125-130页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：pancreatic cancer age at first birth risk factor meta analysis 

摘      要：BACKGROUND： Some studies found that age at first birth is associated with pancreatic cancer; others did not. The present meta-analysis was to evaluate the relationship between age at first birth and pancreatic cancer in *** SOURCES： We searched Pub Med, Embase, and the Cochrane Library for relevant publications on age at first birth and pancreatic cancer up to April, 2014. The eligible studies（six cohorts and five case-controls） were independently selected by two authors. Pooled relative risk（RR） estimates and corresponding 95% confidence interval（95% CI） were calculated using the inverse-variance ***： The pooled RR of pancreatic cancer risk for the highest versus lowest categories of age at first birth was 1.21（95% CI： 1.01-1.45, P=0.314, I^2=13.7%）. Consistent relationships were also observed within subgroup analyses stratified by study design, geographic region, and whether the studies included adjustment for cigarette smoking, diabetes, or all of the confounders. In this meta-analysis, no publication bias among studies was observed using Egger＇s test（P=0.383） or Begg＇s test（P=0.436）.CONCLUSION： Our findings suggest that older age at first birth is associated with an increased risk of pancreatic cancer in women and the exact functional mechanism needs further investigation.