Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy

作     者：Tang Huaying Huang Yinchun Mo Xingneng Yi Guisheng Wen Hui Guo Zhen Feng Kaihua Liu Yin Bu Qing Jiang Wei 

作者机构：Departments of Radiation Oncology Guilin Medical University Affiliated Hospital Departments of Traditional Chinese Medicine Guilin Medical University Affiliated Hospital Departments of Gastroenterology Guilin Medical University Affiliated Hospital Departments of Medical Oncology Guilin Medical University Affiliated Hospital 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2016年第36卷第1期

页      面：45-50页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 10[医学] 

基　　金：Supported by the Scientific Research Fund of the Administration of Traditional Chinese Medicine of Guangxi Province of China:The clinical trial of Chinese Herbal Formula Yunxiangjing Enemas on the treatment of Acute Radiation-Induced Proctitis(No.gzzc 1165) 

主　　题：Pelvic neoplasms Radiation Proctitis Drugs, Chinese herbal Enema Yunxiangjing 

摘      要：OBJECTIVE： To assess the efficacy and safety of Yunxiangjing （YXJ）, derived from Chinese herbal medicine, in the management of acute radiation-induced proctitis （ARIP） in patients with pelvic malignancy. METHODS： Forty-eight patients with grade 2 ARIP were administered YXJ as an enema （I ： 30 dilution） for 2 weeks and followed up for 2 years. All were a sessed for response and ARIP grade. Quality of life （QOL） was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30. RESULTS： Of the 48 patients, six （12.5%） achieved complete remission of ARIP and 28 （58.3%） showed a decrease from grade 2 to grade 1 ARIR No patient experienced a grade 〉3 toxicity. At the end of radio- therapy, patients showed significant improvements in QOL （P 〈 0.05）. Two years after treatment, 46 patients showed no late toxicity, with only two experiencing grade 1 late toxicity. CONCLUSION; YXJ can be used as an enema to manage acute radiation-induced proctitis in cancer patients undergoing radiotherapy. These findings suggest that YXJ enema may be an alternative treatment of ARIP.