The antimicrobial activities of a series of bis-quaternary ammonium compounds

作     者：Xu Zhuo Sun Ning Wang Di Cao Zi Yu Hu Pu Mao Hai Bo Zhang Xiao Hai Zhou 

作者机构：College of Chemistry and Chemical EngineeringHenan University of TechnologyZhengzhou 450001China College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2011年第22卷第8期

页      面：887-890页

核心收录：

学科分类：0820[工学-石油与天然气工程] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 082002[工学-油气田开发工程] 

基　　金：supported by the National Natural Science Foundation of China(No.20972120) Doctor Fund of Henan University of Technology(No.150392) 

主　　题：Bis-quaternary ammonium compounds Antimicrobial activity Surface activity Minimum inhibitory concentrations 

摘      要：A series of bis-quaternary ammonium compounds（bis-QACs） N,N＇-hevamethylenebis（1-alkyl-4-carbamoyl pyridinium bromide）（4BCAP-6,n）（alkyl chain length,n=8,10,12,14,16 and 18） were synthesized and *** surface tensions,critical micelle concentrations（CMC）,and antimicrobial activities were evaluated.4BCAP-6,10 exhibited the strongest antimicrobial activities except for that against Proteus *** activities of 4BCAP-6.n against Escherichia coli zk126 were not significantly influenced by *** and initial bacteria *** results indicate that bis-QACs exhibit high antimicrobial activity regardless of the environmental conditions.