A FACTOR FROM GRANULOSA CELLS CAN STIMULATE OOCYTE TISSUE PLASMINOGEN ACTIVATOR ACTIVITY

作     者：刘以训 LIU YI-XUN Laboratory of Reproductive Biology, Institute of Zoology, Academia Sinica, Beijing 100080, PRC

作者机构：Laboratory of Reproductive Biology Institute of Zoology Academia Sinica Beijing 100080 PRC 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：1989年第32卷第12期

页      面：1449-1456页

核心收录：

学科分类：0810[工学-信息与通信工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 0708[理学-地球物理学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0704[理学-天文学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This work was supported by the Rockefeller Foundation  National Institutes of Health Research Grant and National Natural Science Foundation of China 

主　　题：granulosa cell secretory factor oocyte tissue plasminogen activator (tPA) 

摘      要：Several studies indicate that substances synthesized by granulosa cells are capableof regulating oocyte activity. We have studied the effect of factors synthesized by gran-ulosa cells on tPA activity of denuded oocytes using a co- culture system. The resultsshow that an FSH- dependent factor(s) synthesized by granulosa cells (but not by theca-interstitial cells) is capable of stimulating tPA activity of denuded oocytes. This findingis important for understanding hormonal regulation of oocyte tPA activity by mediatorssynthesized in granulosa cells.