Seeking for endometrial carcinoma-related genes and their bioinformatics analysis

作     者：Yicheng Su Jieqing Zhang Yicheng Su;Jieqing Zhang

作者机构：Department of Gynecologic Oncology the Affiliated Tumor Hospital of Guangxi Medical University Nanning 530021China 

出 版 物：《广西医科大学学报》 (Journal of Guangxi Medical University)

年 卷 期：2017年第34卷第7期

页      面：961-966页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No. 81160318) the Natural Science Foundation of Guangxi Province of China(No.2013GXNSFAA01 9219) 

主　　题：endometrial carcinoma gene chip GEO bioin-formatics analysis 

摘      要：Objective:Screening and excavating genes and biological information related to endometrial carcinoma(EC),to provide novel means for clinical diagnosis and ***:The gene chip data of EC was obtained from the Gene Expression Omnibus(GEO)database,we integrated gene discrepantly expressive gene analysis,enrichment of genic function and pathway analysis,protein-protein interaction(PPI)network and literature mining to predict genes and pathways of ***:Functional enrichment analysis identified 976differential expression genes were participated in cell cycle regulation,proliferation,biosynthesis,protein phosphorylation and fission biological process,*** found eight significantly up-regulated pathways in the microarray datasets,including the MAPK signaling pathway and mTOR pathway,and six down-regulated pathways,including the P53signaling pathway and cell *** protein related interaction network analysis was further performed,and we found twelve distinct genes,including the PCNA and CCND1,these genes were located in key position of EC related network,which may be related to the pathogenesis and progression of ***,there was a high correlation between PCNA and CCND1with EC by consulting the related literature and data,however,the functional mechanism was ***:The pathogenesis and progression of EC may involve in several different pathways and genes,the genes PCNA,CCND1and MAPK signaling pathway may be valuable.