New cytotoxic apigenin derivatives from Selaginella doederleinii

作     者：Zhen-Xing Zou Gui-Shan Tan Guo-Gang Zhang Xia Yu Ping-Sheng Xu Kang-Ping Xu 

作者机构：Xiangya Hospital of Central South UniversityChangsha 410008China Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410013China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第5期

页      面：931-934页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China(No.31370370) Key Project of Application Technology Research and Development of Haikou(No.2015-039) Project of Strategic Emerging Industry Technology Research and Major Scientific and Technological Achievements of Hunan(No.2015GK1053) Innovation Project for Graduate Students of Hunan(No.CX2013B100) 

主　　题：Apigenin derivatives Doederflavones A and B Cytotoxicity 

摘      要：75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC50 values of 0.82 μmol/L and 1.32 μmol/L,respectively.