Effect of dietary supplementation with olive and sunflower oils on lipid profile and liver histology in rats fed high cholesterol diet

作     者：Sandra Mara Pimentel Duavy Gerson Javier Torres Salazar Gerlania de Oliveira Leite Assis Ecker Nilda Vargas Barbosa 

作者机构：Departamento de QuímicaUniversidade Regional do Cariri(URCA)Campus Pimenta Departamento de Bioquímica e Biologia MolecularPrograma de Pós-Graduacao em Ciências Biológicas:Bioquímica ToxicológicaUniversidade Federal de Santa Maria(UFSM)Campus Universitário-Camobi Departamento de FarmacologiaPrograma de Pós-Graduacao em FarmacologiaUniversidade Federal de Santa Maria(UFSM)Campus Universitário-Camobi 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2017年第10卷第6期

页      面：609-613页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100403[医学-营养与食品卫生学] 10[医学] 

基　　金：supported by CAPES the Brazilian Northeast Bank 

主　　题：Cholesterol diets Olive oil Sunflower oil Serum lipids Liver steatosis 

摘      要：Objective: To compare the effects of high-monounsaturated(MUFA) and polyunsaturated fatty acids(PUFA) against the metabolic disorders elicited by a high-cholesterol diet(HC) in rats. Methods: Using in vivo dietary manipulation, rats were fed with different diets containing 4% soybean oil(cholesterol free diet) and 1% HC containing 12% olive oil(HC+OO) enriched with MUFA and 12% sunflower oil(HC+SO) enriched with PUFA for 60 d. Serum lipid levels and hepatic steatosis were evaluated after the treatment period. Results: Comparatively, rats treated with HC+OO diet experienced a decrease in the serum LDL-C, VLDL-C and CT levels compared to those fed with HC+SO diet(P0.05). Otherwise, HC+OO provoked significant microvesicular steatosis situated in the hepatic acinar zone 1. Conclusions: HC+OO diet has high absorption velocity in the acinar zone 1 of liver compared to the HC+SO diet. Based on this, the reduction of the LDL-C, VLDL-C and CT serum levels in the animals treated with HC+OO diet can be caused by the delay in the FA release to the blood.