Antihypertensive and antioxidant activity of Cassytha filiformis L.:A correlative study

作     者：yori yuliandra a.armenia helmi arifin 

作者机构：Faculty of Pharmacy Andalas University Padang West Sumatra Indonesia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2017年第7卷第7期

页      面：614-618页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by Ministry of National Education and Culture  The Republic of Indonesia under the scheme of Fundamental Research [grant number 02/UN.16/PLFD/2013] 

主　　题：Cassytha filiformis Blood pressure Oxidative stress Antioxidant activity Nitric oxide Correlation 

摘      要：Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant ***: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension(HTN group) that received a combination of prednisone and salt for two weeks and oxidative stress-associated hypertension(HTN-OS group) that received additional induction of L-Nitro Arginine Methyl Esther(L-NAME) for two days. Each group was subdivided into 4 and treated intravenously with the extract 5; 10; and 20 mg/kg, and vehicle control. The systolic blood pressure(SBP), diastolic blood pressure(DBP), and mean arterial pressure(MAP) were recorded. The blood was taken before and at the end of recording for the measurement of serum concentration of nitric oxide(NO). The changes of blood pressure were analyzed by two-way ANOVA while its correlation with NO concentration was analyzed by Pearson s ***: The study showed a significant antihypertensive effect of the extract as compared with control group(P 0.05).Conclusions: The study concludes that C. filiformis extract in the dose of 5 mg/kg exhibits the best blood pressure lowering effect in both animal models. Antihypertensive activity of the extract is not correlated with its antioxidant effect.