Synthesis,characterization and antibacterial screening of some novel 1,2,4-triazine derivatives

作     者：Mohammad Arshad Abdul Roouf Bhat Kwon Kang Hoi Inho Choi Fareeda Athar 

作者机构：Centre for Interdisciplinary Research in Basic SciencesJamia Millia lslamiaNew Delhi 110025India College of Medicine Aldawadmi Shaqra UniversitySaudi Arabia P.G.Department of ChemistrySri Pratap CollegeSrinagarJ&K190001India School of BiotechnologyYeungnam UniversityGyeongsan 712-749South Korea 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第7期

页      面：1559-1565页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：UGC(No.F no-43-172/2014(SR)) UGC MANF scheme wide letter No.F.40-65(C/M)/2009(SA-III/MANF)for providing financial assistance 

主　　题：Synthesis 1 2 4-Triazine Antibacterial activity Toxic effects MTT-assay 

摘      要：A new series of 1, 2, 4-triazine derivatives possessing indole nucleus were synthesized with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection. In vitro antimicrobial activity was performed against S. aureus, S. epidermidis, P. mirabilis and E. coli using disk diffusion method. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibition area/mg of the compounds with the standard drug ＂Ciprofloxacin＂.Selected compounds were evaluated for toxic effects using human hepatocellular carcinoma（HepG2） cell line by MTT-assay. Results revealed that some compounds of the series were found to exhibit better activity with less toxicity than Ciprofloxacin