Brain changes detected by functional magnetic resonance imaging and spectroscopy in patients with Crohn's disease

作     者：Kun Lv Yi-Hong Fan Li Xu Mao-Sheng Xu 

作者机构：The First Clinical Medical College of Zhejiang Chinese Medical University Department of RadiologyThe First Affiliated Hospital of Zhejiang Chinese Medical University Department of GastroenterologyThe First Affiliated Hospital of Zhejiang Chinese Medical University Department of ColoproctologyThe First Affiliated Hospital of Zhejiang Chinese Medical University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第20期

页      面：3607-3614页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China,No.81473506 the Natural Science Foundation of Zhejiang Province,No.LY17H290009 the Ministry of Construction,Zhejiang Province,No.WKJ-ZJ-1531 

主　　题：Brain-gut-enteric microbiota axis Crohn’s disease Functional magnetic resonance spectroscopy Functional magnetic resonance imaging Gut microbiota Inflammatory bowel disease Metabolite Spectroscopy 

摘      要：Crohn’s disease(CD)is a chronic,non-specific granulomatous inflammatory disorder that commonly affects the small intestine and is a phenotype of inflammatory bowel disease(IBD).CD is prone to relapse,and its incidence displays a persistent increase in developing ***,the pathogenesis of CD is poorly understood,with some studies emphasizing the link between CD and the intestinal ***,studies point to the brain-gut-enteric microbiota axis as a key player in the occurrence and development of ***,investigations have shown whitematter lesions and neurologic deficits in patients with *** on these findings,brain activity changes in CD patients have been detected by blood oxygenation level dependent functional magnetic resonance imaging(BOLD-f MRI).BOLD-f MRI functions by detecting a local increase in relative blood oxygenation that results from neurotransmitter activity and thus reflects local neuronal firing ***,biochemical concentrations of neurotransmitters or metabolites may change in corresponding brain regions of CD *** further study this phenomenon,brain changes of CD patients can be detected non-invasively,effectively and accurately by BOLD-f MRI combined with magnetic resonance spectroscopy(MRS).This approach can further shed light on the mechanisms of the occurrence and development of neurological ***,this paper reviews the current status and prospects on fMRI and MRS for evaluation of patients with CD based on the brain-gut-enteric microbiota axis.