Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats

作     者：Teng Liu Ming-Wei Zhong Yi Liu Xin Huang Yu-Gang Cheng Ke-Xin Wang Shao-Zhuang Liu San-Yuan Hu 

作者机构：Department of General Surgery Qilu Hospital of Shandong University Health and Family Planning Commission of Shandong Provincial Medical Guidance Center 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第18期

页      面：3269-3278页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China,No.81471019(to Hu SY)and No.81300286(to Liu SZ) Foundation for Outstanding Young Scientist in Shandong Province,No.BS2013YY031(to Liu SZ) Science and Technology Development Program of Shandong Province,No.2014GGE27485(to Liu SZ) Specialized Research Fund for the Doctoral Program of Higher Education of China,No.20130131120069(to Liu SZ) 

主　　题：Sleeve gastrectomy Trunk vagotomy Glucose metabolism GLP-1 Ghrelin 

摘      要：AIM To investigate the effects of sleeve gastrectomy plus trunk vagotomy(SGTV) compared with sleeve gastrectomy(SG) in a diabetic rat *** SGTV, SG, TV and Sham operations were performed on rats with diabetes induced by high-fat diet and streptozotocin. Body weight, food intake, oral glucose tolerance test, homeostasis model assessment of insulin resistance(HOMA-IR), hepatic insulin signaling(IR, IRS1, IRS2, PI3 K and AKT), oral glucose stimulatedinsulin secretion, GLP-1 and ghrelin were compared at various postoperative *** Both SG and SGTV resulted in better glucose tolerance, lower HOMA-IR, up-regulated hepatic insulin signaling, higher levels of oral glucose-stimulated insulin secretion, higher postprandial GLP-1 and lower fasting ghrelin levels than the TV and Sham groups. No significant differences were observed between the SG and SGTV groups. In addition, no significant differences were found between the TV and Sham groups in terms of glucose tolerance, HOMA-IR, hepatic insulin signaling, oral glucose-stimulated insulin secretion, postprandial GLP-1 and fasting ghrelin levels. No differences in body weight and food intake were noted between the four *** SGTV is feasible for diabetes control and is independent of weight loss. However, SGTV did not result in a better improvement in diabetes than SG alone.