Salivary IgA enhancement strategy for development of a nasal-spray anti-caries mucosal vaccine

作     者：YAN HuiMin 

作者机构：Mucosal Immunity Research GroupState Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2013年第56卷第5期

页      面：406-413页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the National Key Research and Development Program,Ministry of Science and Technology of China(2007BAI28B04) the National Science and Technology Major Project on Major Infectious Diseases(2012ZX10001-008,2008ZX10001-010) 

主　　题：mutans streptococci secretory IgA PAc mucosal immunization caries vaccine 

摘      要：Dental caries remains one of the most common global chronic diseases caused by Streptococcus mutans,which is prevalent all over the *** caries prevalence of children aged between 5-6 years old in China is still in very high rate.A potent and effective anti-caries vaccine has long been expected for caries prevention but no vaccines have been brought to market till now mainly due to the low ability to induce and maintain protective antibody in oral *** review will give a brief historical retrospect on study of dental caries and pathogenesis,effective targets for anti-caries vaccines,oral immune system and immunization against dental ***,salivary IgA antibodies and the protective responses are discussed in the context of the ontogeny of mucosal immunity to indigenous oral *** methods and advancement for induction of specific anticaries salivary sIgA antibodies and enhancement of specific anti-caries salivary sIgA antibodies by intranasal immunization with a safe effective mucosal adjuvant are *** progress in the enhancement of salivary sIgA antibodies and anticaries protection by intranasal immunization with flagellin-PAc fusion protein will be ***,some of the main strategies that have been used for successful mucosal vaccination of caries vaccine are reviewed,followed by discussion of the mucosal adjuvant choice for achieving protective immunity at oral mucosal membranes for development of a nasal-spray or nasal-drop anti-caries vaccine for human.