Glutathione S-transferase P1 IlelO5Val Polymorphism and Male Infertility Risk： An Updated Meta-analysis

作     者：Xue-Kun Huang Yong-Han Huang Juan-Hua Huang Jing-Yao Liang Huang Xue-Kun;Huang Yong-Han;Huang Juan-Hua;Liang Jing-Yao

作者机构：Department of Obstetrics and Gynaecology Reproductive Medicine Center The First People's Hospital of Foshan Foshan Guangdong 528000 China Department of Dermatology Institute of Dermatology Guangzhou Medical University Guangzhou Guangdong 510095 China Department of Dermatology Institute of Dermatology Guangzhou Institute of Dermatology Guangzhou Guangdong 510095 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2017年第130卷第8期

页      面：979-985页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Glutathione S-transferase PI Male Infertility： Polymorphism 

摘      要：Background： Several studies concerning the association between glutathione S-transferase P1 （GSTP1） Ilel05Val polymorphism and male infertility risk have reported controversial findings. The present study was aimed to explore this association using a recta-analysis. Methods： The PubMed, EMBASE, China National Knowledge Infrastructure （CNKI）, and Wanfang databases were searched. Odds ratios （ORs） with 95% confidence intervals （C/s） were calculated to estimate the strength of the association. Results： A total of 3282 cases and 3268 controls in nine case-control studies were included. There was no significant association between GSTP1 llel05Val polymorphism and male infertility in the overall population, but significant associations were lbund under the dominant （OR = 1.23, 95% CI = 1.04-1.46, F = 32.2%） and heterozygote （OR = 1.29, 95% C1 - 1.08-1.53, F = 26.8%） models after excluding studies for which the data did not satisfy Hardy-Weinberg equilibrium （HWE）. Similarly, subgroup analyses revealed no significant association in Asians or Chinese population although a significant association was apparent among Chinese population in studies with HWE under the heterozygote model （OR = 1.25, 95% CI = 1.03-1.52, F = 44.1%）. Significant heterogeneity could be observed in some genetic models, but this heterogeneity was not significant when stratified by HWE. No evidence for publication bias was found. Conclusions： The GS-FP1 lle105Val polymorphism might not be associated with male infertility risk, and thus additional well-designed studies with larger sample size are warranted.