An Expanded View of Complex Traits:From Polygenic to Omnigenic
作者机构：Department of Genetics Stanford University Stanford CA 94305 USA. Electronic address: eaboyle@stanford.edu. Department of Genetics Stanford University Stanford CA 94305 USA. Electronic address: yangili@stanford.edu. Department of Genetics Stanford University Stanford CA 94305 USA Department of Biology Stanford University Stanford CA 94305 USA Howard Hughes Medical Institute Stanford University Stanford CA 94305 USA. Electronic address: pritch@stanford.edu.
出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)
年 卷 期：2024年第46卷第1期
页 面：139-139页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学]
基 金：National Human Genome Research Institute NHGRI (R01HG008140)
摘 要：A central goal of genetics is to understand the links between genetic variation and ***,one might expect diseasecausing variants to cluster into key pathways that drive disease *** for complex traits,association signals tend to be spread across most of the genome-including near many genes without an obvious connection to disease.
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