Six-step synthesis of Leonurine and toxicity study on zebrafish

作     者：Hui Zhao Xiang-Guo Hu Min-Jie Xu Qun-Xing Cai Yu-Jun Liu Duo-Meng Su Shi-Jin Chen Kai Wang Zhu-Nan Gong 

作者机构：Anhui Engineering Technology Research Center for Extraction and Isolation of Active Components Anhui Academy of Applied Technology Hefei 230031China National Engineering Research Center for Carbohydrate Synthesis Jiangni Normal University Nanchang 330022 China School of Life Science Nanjing Normal University Nanjing 210023 China Anhui Academy of Science and Technology Hefei 230031 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第6期

页      面：1172-1175页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Anhui Ph.D.Programs of Postdoctoral Workstation,Talents Program of Hefei funds from the sixth group of Anhui '115' Industrial Innovation Team(Team of Key Technology Innovation on Botanical Pesticides) 

主　　题：Leonurine Zebrafish Synthesis Toxcity Oxime 

摘      要：Leonurine（1）,an important ingredient in leonurus sibiricus L,can be used for some gynecological *** have developed a concise and efficient synthetic route of Leonurine,which can be optimized for mass *** available compound 6 and 2,3-dihydrofuran（7） were used as starting *** the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.