The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

作     者：Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo 

作者机构：The Affiliated Nanhua HospitalUniversity of South ChinaHengyangHunan 421001China School of MedicineUniversity of South ChinaHengyangHunan 421001China Medical SchoolShaoyang UniversityShaoyangHunan 422000China Department of Respiratory and Critical Care MedicineZhangjiajie City HospitalZhangjiajieHunan 427000China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2017年第4卷第1期

页      面：19-24页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Grant sponsor:National Nature Science Foundation of China,Grant number:81272960 Key Research Program from Science and Technology Department of Hunan Province China,Grant number:2013WK2010 and 2014SK2015 The fund of Tianqing liver disease research This work was supported by National Nature Science Foundation of China(81272960) Key Research Program from Science and Technology Department of Hunan Province,China(2013WK2010 and 2014SK2015) Key Research Program from Ministry of human Resources and Social Security of the People’s Republic of China(2016)176 

主　　题：Angiogenesis HIF Hypoxia Metabolism VHL 

摘      要：Hypoxia-inducible factor(HIF)is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible *** is frequently upregulated in solid tumors,and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular *** this review,we focused on the pivotal role of HIF in tumor angiogenesis and energy ***,we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer.