The in vitro and in vivo toxicity of gold nanoparticles

作     者：Yan-Peng Jia Bu-Yun Ma Xia-Wei Wei Zhi-Yong Qian 

作者机构：State Key Laboratory of Biotherapy Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University Chengdu 610041 China Department of Ultrasound West China Hospital Sichuan University Chengdu 610041 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第4期

页      面：691-702页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 070301[理学-无机化学] 0702[理学-物理学] 

基　　金：financially supported by the National Natural Science Foundation of China(No.31525009) Sichuan Innovative Research Team Program for Young Scientists(No.2016TD0004) 

主　　题：Gold nanoparticles Toxicity Size Shape Surface modification In vitro In vivo 

摘      要：Gold nanoparticles,owing to their unique physicochemical and optical properties,well-established synthetic methods and easy modifications,have been widely used in biomedical ***,for their safe and efficient applications,much attention has been given to the toxicological evaluations of gold nanoparticles in biological systems.A large number of studies focusing on this problem have been carried out during the past ***,the researches on gold nanoparticles toxicity still remain fragmentary and even contradictory with each *** may be caused by the variety in experimental *** this review,we aim to provide a better understanding about the in vitro and in vivo toxicity of gold nanoparticles by reviewing and describing the up to date literatures related to this problem and we mainly focused on these properties such as the particle size and shape,the surface charge and ***,we also summarized the adverse effect of gold nanoparticles on immune systems and analyzed the origin of the toxicity.