Diagnostic and therapeutic potentials of microRNAs in cholangiopathies
作者机构：ResearchCentral Texas Veterans Health Care SystemTempleTXUSA Department of MedicineTexas A&M Health Science CenterCollege of MedicineTempleTXUSA Baylor Scott&White Digestive Disease Research CenterBaylor Scott&White HealthTempleTXUSA
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2017年第1卷第1期
页 面：34-41页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported in part by the Dr.Nicholas C.Hightower Centennial Chair of Gastroenterology from Scott&White,a VA Research Career Scientist Award,a VA Merit award to Dr.Alpini(5I01BX000574) a VA Merit Award(1I01BX003031)to Dr.Francis,a VA Merit Award(5I01BX002192)to Dr.Glaser a VA Merit Award(1I01BX001724)to Dr.Meng from the United States(U.S.)Department of Veterans Affairs Biomedical Laboratory Research a NIH grant DK108959 to Dr.Francis,and the multiple-PIs NIH grants DK058411,DK076898,DK107310 and DK062975 belong to Drs.Alpini,Meng and Glaser
主 题：microRNAs Cholangiopathies Diagnosis Therapy
摘 要：Cholangiopathies are a group of rare,devastating diseases that arise from damaged cholangiocytes,the cells that line the intra-and extra-hepatic bile ducts of the biliary *** result in significant morbidity and mortality and are a major cause of liver transplantation.A better understanding of the underlying pathogenesis that influences cholangiocyte dysregulation and cholangiopathy progression is necessary,considering the dismal prognosis associated with these *** are a class of small,non-coding RNAs that regulate post-transcriptional mRNA expression of specific *** role of microRNAs has expanded to include the initiation and development of many diseases,including *** microRNA regulation of cholangiopathies may provide diagnostic and therapeutic benefit for these *** this review,the authors primarily focus on studies published within the last five years that help determine the diagnostic and therapeutic potential of microRNAs in cholangiopathies.
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