Megastigmane glucosides isolated from Dichrocephala benthamii

作     者：SONG Bo SI Jin-Guang YU Meng TIAN Xiao-Hui DING Gang ZOU Zhong-Mei 

作者机构：Institute of Medicinal Plant DevelopmentPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100193China Henan University of Traditional Chinese Medicine Zhengzhou 450016China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2017年第15卷第4期

页      面：288-291页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported financially by the Chinese National S&T Special Project on Major New Drug Innovation(No.2013ZX09508104) Innovative Research Team in Institute of Medicinal Plant Development(IMPLD) 

主　　题：Asteraceae Dichrocephala benthamii Megastigmane glucoside Cytotoxicity 

摘      要：The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside(compound 1), together with its four known analogues(compounds 2-5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses(UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells(Hep G-2) was evaluated by the MTT method. Compound 5 showed weak activity against Hep G-2, while the other compounds did not show remarkable inhibitory effects.