Understanding peroral absorption:regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles

作     者：Prachi B.Shekhawat Varsha B.Pokharkar 

作者机构：Department of PharmaceuticsPoona College of PharmacyBharati Vidyapeeth Deemed UniversityErandwaneKothrudPune 411038India 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2017年第7卷第3期

页      面：260-280页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Department of Science and Technology New Delhi for providing financial assistance under Women Scientist Scheme-A(SR/WOS-A/LS-248/2012) 

主　　题：BCS Solubility Permeability Formulation strategies Factors affecting absorption 

摘      要：Oral drug absorption is a process influenced by the physicochemical and biopharmaceutical properties of the drug and its inter-relationship with the gastrointestinal tract. Drug solubility, dissolution and permeability across intestinal barrier are the key parameters controlling absorption. This review provides an overview of the factors that affect drug absorption and the classification of a drug on the basis of solubility and permeability. The biopharmaceutical classification system(BCS) was introduced in early90 s and is a regulatory tool used to predict bioavailability problems associated with a new entity, thereby helping in the development of a drug product. Strategies to combat solubility and permeability issues are also discussed.