Pluripotency and its layers of complexity

作     者：Jolene Ooi Pentao Liu 

作者机构：Wellcome Trust Sanger InstituteHinxton CB101SAUK Technology and ResearchAgency for Science1 Fusionopolis Way#20-10Connexis North Tower 138632Singapore. 

出 版 物：《Cell Regeneration》 (细胞再生（英文）)

年 卷 期：2012年第1卷第1期

页      面：47-56页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Naïve pluripotency Primed pluripotency Embryonic stem cells Induced pluripotent stem cells Epiblast stem cells 

摘      要：Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ *** stages of early murine development can be captured on a petri dish,delineating a spectrum of pluripotent states,ranging from embryonic stem cells,embryonic germ cells to epiblast stem *** cell populations displaying signs of pluripotency have also been uncovered,from the isolation of embryonic carcinoma cells to the derivation of induced pluripotent stem *** insight into the molecular circuitry within these cell types enlightens us about the significance and contribution of each stage,hence deepening our understanding of vertebrate *** this review,we aim to describe experimental milestones that led to the understanding of embryonic development and the conception of *** also discuss attempts at exploring the realm of pluripotency with the identification of pluripotent stem cells within mouse teratocarcinomas and embryos,and the generation of pluripotent cells through nuclear *** conclusion,we illustrate pluripotent cells derived from other organisms,including human derivatives,and describe current paradigms in the comprehension of human pluripotency.