Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins

作     者：Xiaonan Zhuang Zijuan Chen Chenxi He Lin Wang Ruixue Zhou Dapeng Yan Baoxue Ge 

作者机构：Department of Immunology and Key Laboratory of Medical Molecular Virology of MOE/MOH School of Basic Medical Sciences Fudan University Shanghai 200032 China Department of Microbiology and Immunology Tongji University School of Medicine Shanghai 200092 China Shanghai Key Laboratory of Tuberculosis Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200092 China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2017年第14卷第3期

页      面：237-244页

核心收录：

学科分类：0710[理学-生物学] 090603[农学-临床兽医学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 09[农学] 0906[农学-兽医学] 071009[理学-细胞生物学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：上海市浦江人才计划项目 sponsored by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning 

主　　题：NF-κB 埃希氏菌属 肠致病性大肠杆菌 蛋白激酶类 蛋白质类 胰岛素 有丝分裂原 综述 

摘      要：To successfully infect host cells and evade the host immune response, a type III secretion system （T3SS） is commonly used by enteric bacterial pathogens such as enteropathogenic Escherichia coil （EPEC）. Recent findings have revealed that various effectors are injected into host cells through the T3SS and exert an inhibitory effect on inflammatory signaling pathways, subverting the immune responses to these pathogens. Here we review recent studies aimed at addressing the modulation of several important inflammatory signaling pathways modulated by EPEC effector proteins, such as the nuclear factor-KB （NF-KB） and mitogen-activated protein kinase （MAPK） pathways, which provides insight into the unfinished work in this unexplored field and helps to identify novel positions in inflammatory signaling networks for EPEC effectors.