Association analysis between HFM1 variations and idiopathic azoospermia or severe oligozoospermia in Chinese Men

作     者：Wenxiang Zhang Xiaomin Song Feng Ni Jinbao Cheng Bai-Lin Wu Hong Jiang 

作者机构：Clinical College of PLA Affiliated Anhui Medical UniversityHefei 230031China Reproductive Medicine Centerthe 105^th hospital of PLAHefei 230031China Children's Hospital of Fudan UniversityInstitute of Biomedical ScienceShanghai Medical College of Fudan UniversityShanghaiChina 200032 Boston Children's Hospital and Harvard Medical SchoolBostonMA 02115USA 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2017年第60卷第3期

页      面：315-318页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81501216) Anhui Provincial Natural Science Foundation(1608085MH165) supported in part by the National Basic Research Program of China grants from the Ministry of Science and Technology of China(2013CB945404 and 2010CB529601) 

主　　题：无精子症 相关性分析 男人 中国 

摘      要：Dear Editor,Infertility affects 10%?15%of couples trying to conceive,with male factors contributing to as many as 50%of infertile cases(Meng et al.,2015).Azoospermia or severe oligozoospermia(oligo/azoospermia),clinically characterized by a complete or partial absence of sperm in the ejaculate,account for 10%?15%of male infertility(Wosnitzer et al.,2014).Approximately 20%?30%of men with oligo/azoospermia are attributed to the known genetic factors,