Evaluation of Tablets Containing a Probiotic Strain for an Oral Administration
Evaluation of Tablets Containing a Probiotic Strain for an Oral Administration作者机构：Department of Pharmacy and Pharmaceutical Technology Faculty of Pharmacy University of Granada Granada 18071 Spain
出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)
年 卷 期：2017年第5卷第4期
页 面：194-206页
学科分类：1007[医学-药学(可授医学、理学学位)] 090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 10[医学]
主 题：Lactobacillus coryniformis matrix tablets retarding polymers health.
摘 要：The scientific concept of probiotics has been widely accepted throughout the last decades; consequently, its industrial production and commercialization have been increased. This is only the beginning since a recent global probiotic market analysis estimated an annual growth, boosted mainly by a rising request from the Asian and European consumer in the next 5 years. So the pharmaceutical industry needs to develop new dosage forms containing probiotic microorganisms in order to offer consumers a variety of products. Different kinds of matrix tablets with Lactobacillus coryniformis CECT 5711 were designed to protect this strain from the technological process and harsh gastrointestinal conditions up until their arrival in the gut, as well as environmental conditions during their storage. With this aim, various retarding polymers were combined so as to get controlled release tablets. All formulations were evaluated in terms of technological processability, bacterial viability and stability. Finally, an optimal formulation with Methocel K-15 M EP, Eudragit L-100 and alginate sodium, which contain Lactobacillus coryniformis CECT 5711, was selected due to the fact that it assured an excellent survival of the microorganisms after their exposition to all conditions mentioned above, besides it will be able to improve human＇s health.
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