(188)~Re-labeled McAb 3H11 used as preventive for the peritoneal micrometasis of gastric cancer

作     者：YANGZhi ZHANGMeiying 等 

作者机构：SchoolofClinicalOncologyBeijingMedicalUniversityandBeijingCancerHospitalBeijing100036 SchoolofClini 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：1999年第10卷第4期

页      面：203-206页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 100106[医学-放射医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：胃癌 188Re示踪 单克隆抗体 

摘      要：In advancing gastric cancer,especially when the serous is invaded,the plantation of cancer cells in peritoneal is common and it affects patients survival time *** on sucessfully labeled McAb(monoclonal antibody) 3H11 with ^188Re,we investigated the effect of RIT(Radioimmuno-Therapy) with ^188Re-3H11 on preventing the survival time,After 1×10^6 BGC-823 gastric cancer cells were injected into the peritoneal cavity of each mouse,45MABL/C nude mice were divided into 9 *** group received different doses of ^188Re-3Hll or 188Re-IgG,or saline I.P.16 hours *** injected volume of each mouse was *** results showed that the survival time depended on the injected doses during 0 to *** survival time was 170±25.3d after 37MBq 188^Re-3H11 were *** was over 5 times more than that for the saline gro9up and about 3 times more than that for 37MBq 188-Re IgG group(P0.05),The mice hemogram were reduced to lowest 14days after injection,but they recovered after ***:with proper injection doses,early postoperative ^188Re-3H11 *** effective and safe for the prevention of intra-peritoneally injected gastric cancer cells from surviving,growing and disseminating in nude mice.