A novel bioactive nerve conduit for the repair of peripheral nerve injury

作     者：Bin-bin Li Yi-xia Yin Qiong-jiao Yan Xin-yu Wang Shi-pu Li 

作者机构：State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of Technology Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of Technology 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究(英文版))

年 卷 期：2016年第11卷第1期

页      面：150-155页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a grant from the National Key Basic Research Program of China,No.2011CB606205 a grant from the National Natural Science Foundation of China,No.51403168 a grant from the Major Scientific and Technological Research Projects of the Ministry of Education of China,No.313041 a grant from the Scientific and Technological Cooperation Projects of Hong Kong,Macao and Taiwan,China,No.2015DFH30180 

主　　题：nerve regeneration polylactic acid poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]} β-tricalcium phosphate nerve conduit nerve fiber neural regeneration 

摘      要：The use of a nerve conduit provides an opportunity to regulate cytokines,growth factors and neurotrophins in peripheral nerve regeneration and avoid autograft *** constructed a poly-D-L-lactide(PDLLA)-based nerve conduit that was modified using poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]}andβ-tricalcium *** effectiveness of this bioactive PDLLA-based nerve conduit was compared to that of PDLLA-only conduit in the nerve regeneration following a 10-mm sciatic nerve injury in *** observed the nerve morphology in the early period of regeneration,35 days post injury,using hematoxylin-eosin and methylene blue *** with the PDLLA conduit,the nerve fibers in the PDLLA-based bioactive nerve conduit were thicker and more regular in *** fibers in the soleus muscle had greater diameters in the PDLLA bioactive group than in the PDLLA only *** PDLLA-based bioactive nerve conduit is a promising strategy for repair after sciatic nerve injury.