Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride

作     者：Ahmed Awadallah-F Tahia B.Mostafa 

作者机构：National Center for Radiation Research and Technology Chemistry DepartmentUniversity College for WomenAin Shams University 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2015年第33卷第3期

页      面：376-385页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 070301[理学-无机化学] 

主　　题：Polymer grafting Gamma irradiation Multi-walled carbon nanotubes Controlled release Tramdol hydrochloride. 

摘      要：Multi-walled carbon nanotubes （MWCNTs） were grafted with poly（N-vinyl-2-pyrrolidone） and with poly（2- acrylamido-2-methyl-1-propanesulfonic acid） at different compositions by using y-rays technique as initiator. The MWCNTs, MWCNT-graft-PNVP, MWCNT-graft-PAMPS and MWCNTs-graft-P（NVP-co-AMPS） were characterized by Fourier transform infra red （FTIR） spectroscopy, X-ray diffraction （XRD）, thermal gravimetric analysis （TGA）, elemental analysis and high-resolution transmission electron microscopy （HR-TEM）. The results indicated that the grafting processes of PNVP, PAMPS and P（NVP-co-AMPS） occurred on to the surfaces of MWCNTs without destroying the framework of MWCNTs. Tramadol hydrochloride （TH） was loaded as model drug and its release behavior was analyzed via various kinetic models. Release of the loaded TH was studied in simulated gastric fluid （SGF, pH = 1.2） and simulated intestinal fluid （SIF, pH = 7.4） at 37 ℃. Controlled release of TH from grafted MWCNTs was investigated. The outcome results suggest that the grafted MWCNTs could be used as a promising matrix candidate for oral drug delivery system by harmonization between the composition and pH level of the simulated biological fluids.