Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia

作     者：Qinhua Guo Jin Lan Weiqiao Zhang Pin Guo Liemei Guo Zhiqiang Li Yongming Qiu 

作者机构：Department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Central Hospital of Fengxian District Shanghai Neurological Research Institute of Anhui University of Science ＆ Technology Shanghai201400 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第2期

页      面：125-130页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学] 071002[理学-动物学] 

基　　金：supported by the National Natural Science Foundation of China, No. 81171168 Shanghai Science and Technology Committee, No. 10140903200 

主　　题：apoptosis excitatory amino acid carrier 1 global cerebral ischemia glutamate-aspartate transporter glutamate transporter glutamate transporter-1 neuroprotection 

摘      要：The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and hippocampus. After 24 hours of ischemia, expression of glutamate transporter-1 significantly decreased in the cerebral cortex and hippocampus, which was accompanied by neuronal necrosis. At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis Expression of glutamate-aspartate transporter remained unchanged at 6 hours 7 days after ischemia. These results suggested that glutamate transporter levels were altered at different periods of cerebral ischemia.