Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats

作     者：Haiyu Guo Young-Hwan Ban Yeseul Cha Tae-Su Kim Sung-Pyo Lee Eun Suk An Jieun Choi Da Woom Seo Jung-Min Yon Ehn-Kyoung Choi Yun-Bae Kim 

作者机构：Veterinary Medical Center and College of Veterinary Medicine Chungbuk National University Cheongiu Chungbuk Republic of Korea Anydoctor Healthcare Co. Ltd. Cheonan Chungnam Republic of Korea 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2017年第31卷第2期

页      面：122-129页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the "Food Functionality Evaluation Program" under the Ministry of Agriculture, Food and Rural Affairs partly Korea Food Research Institute(G2015) 

主　　题：plant oil trans-fat blood lipid body fat ischemic stroke physical activity 

摘      要：Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases, the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated. Sprague- Dawley rats were fed a diet containing the oils or trans-fat, and then body weights, blood lipids, and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion （MCAO） were analyzed. All the oils and trans-fat, except perilla oil, significantly increased body fats and body weight gain. Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides, respectively, while perilla oil decreased both cholesterols and triglycerides. Perilla oil not only attenuated cerebral infarction, but also restored locomotor activity and rota-rod performances of MCAO rats. It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke.