RELATIONSHIP　BETWEEN　THE　MUTATION　OF　P53　GENE　AND　INFILTRATION，METASTASIS　AND　PROGNOSIS　OF　GASTRIC　CARCINOMA

作     者：辛彦 赵凤凯 吴东瑛 王艳萍 徐蕾 张荫昌 

作者机构：Cancer Institute China Medical University Shenyang Department of Histopathology Charring Cross & Westminster Medical School University of London UK 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：1996年第8卷第4期

页      面：263-266页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：p53 gene Tumor suppresser gene.Metastasis Gastric carcinoma 

摘      要：gastric carcinomas were examined immunohistochemically with McAb to p53 protein in order to investigate the relationship between the expression of p53 protein and histological differentiation of gastric carcinoma, and to approach the mechanism of infiltration and metastasis of gastric carcinoma. The results showed that nuclear expression of p53 protein was significantly related to tumor size, depth of invasion, lymph node and liver metastases; but not related to histological differentiation. It is suggested that the accumulation of p53 protein was increased with the progression of gastric carcinoma, and therefore the cancer clone with p53 gene mutation may play an important role in the development of tumor invasion and metastasis.