Urinary follicle stimulating hormone can be used as a biomarker to assess male reproductive function

作     者：Xin-RuWANG JamesWOverstreet HeatherTodd QingQIU Jiang-HuaYANG Shu-YiWANG Xi-PingXU BillLLasley 

作者机构：SchoolofPublicHealthNanjingMedicalUniversity.Nanjing210029China InstituteofToxicologyandEnvironmentalHealth.UniversityofCaliforniaDavisCalifornia95616USA AnhuiMeizhongInstitureforBiomedicalScienceandEnvironmentalHealthAnludChina SchoolofPublicHealthHarvardUniversityBostonMassachusetts02115USA 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：1999年第1卷第1期

页      面：67-72页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Project supported by National Institute of Health Grants ES04699  ES06198 and ES05707 

主　　题：follicle stimulating hormone sperm count reproduction testis spermatozoa urine urinalysis 

摘      要：Aim: To develop an algorithm for use in population-based studies to assess testicular function by measurements of totalurinary follicle stimulating hormone (FSH). Methods: Total concentrations of urinary FSH were measured in a groupof 44 men at the University of California, Davis (UCD) and were compared to FSH measurements in serum. On thebasis of these and other published data, a urinary FSH value of 2 ng/mg creatinine (Cr) was selected as the cutoffpoint to identify men with elevated serum FSH ( 12 IU/L) or low sperm counts ( 20 million/mL). Results: Thesensitivity and specificity of this algorithm for detecting elevated serum FSH in a group of 58 agricultural workers in thePeople s Republic of China were 100 % and 50 %, respectively. The sensitivity and specificity of this algorithm fordetecting low sperm counts in a population of 105 infertility patients at UCD were 58 % and 76 %, ***: This test may have particular value in identifying populations with no evidence of testicular toxicity, andin which labor-intensive semen studies may not be feasible.