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Research on pharmacological mechanism of the treatment of Asthma by oral Bordetella pertussis

Research on pharmacological mechanism of the treatment of Asthma by oral Bordetella pertussis

作     者:CHI Shen,SUN Yun,ZHANG Bao-yuan(Medical College of Yangzhou University,Yangzhou 225001,China) 

出 版 物:《沈阳药科大学学报》 (Journal of Shenyang Pharmaceutical University)

年 卷 期:2008年第25卷第S1期

页      面:115-116页

学科分类:1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100602[医学-中西医结合临床] 10[医学] 

主  题:asthma airway inflammation Bordetella pertussis bral eosinophils 

摘      要:Objective To examine the effect of oral Bordetella pertussis on the asthma mice sensitized by ovalbumin(OVA),and explore the possible *** Culture the *** in Bordet-Gengou agar containing 25% rabbit *** the bacteria and inactive them at 80 ℃ for 30 min to get whole killed ***.32 BALB/C mice were randomly divided into control group,model-control group,model group and treatment *** mice were sensitized and challenged with OVA to establish asthma *** mice in treatment group were orally administrated with *** 7 days before *** mice in control group and model-control group were challenged with *** 24 hours of last challenge,bronchoaveolar lavage fluid(BALF)and peripheral blood were *** total cells and eosinophils were counted in *** Compared with the control group(2.03±0.42,0.33±0.82)×105 mL-1 and model-control group(2.16±0.48,0.16±0.41)×105 mL-1,the total cells(10.13±1.33)×105 mL-1 and eosinophils(11.83±4.573)×105 mL-1 in BALF were more in asthma mice(P0.01).The number of total cells(5.50±1.55)×105 mL-1 and eosinophils(0.66±0.82)×105 mL-1 in BALF were reduced in asthma mice treated with *** compared with asthma mice(P0.01).Conclusions Oral *** can inhabit airway inflammation of asthma mice and has the potential of treating asthma.

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